General Cell Lines and Cell Cultures
ATCC Salmonella enterica; subspecies enterica; serovar Newport; Strain: SAP18-8729
Salmonella enterica subsp. enterica serovar Newport strain SAP18-8729 is a whole-genome sequenced bacterium that was part of the 2018 PulseNet-GenomeTrakr joint proficiency test exercise. This strain has applications in infectious disease research and zoonotic disease research.
ATCC Salmonella enterica; subspecies enterica; serovar Enteritidis; Strain: SAP18-H9654
Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-H9654 was isolated in the United States from human feces. This whole-genome sequenced bacterium was part of the 2018 PulseNet-GenomeTrakr joint proficiency test exercise. This strain has applications in infectious disease research and zoonotic disease research.
ATCC Aspergillus clavatus; Kral; genomic DNA
Genomic DNA isolated from Aspergillus clavatus QM 1276. This fungal strain is also available as ATCC Catalog No.: 1007™.
MOLTOX Molecular Toxicology Inc Sprague-Dawley Rat Liver S9, Male, Uninduced, 0.154M KCL, 2 mL/vial, Store in Ultra-low
Uninduced Sprague Dawley Rat Liver S9. For use in control experiments. This S9 is prepared with untreated tissue. It is imperative that frozen S9 preparations remain in storage conditions of around -80C, requiring expedited shipping on dry ice and careful temperature considerations during the thaw process. Once thawed your S9 is ready for use with cofactors. MOLTOX S9 preparations and cofactor reagents for use in metabolic activation studies are manufactured to rigorous standards of quality and performance and are used by leading industrial, government and academic laboratories worldwide. *Non Returnable*
ATCC Monoclonal Antibody;Anti-SARS-CoV-2 Receptor; Binding Domain (RBD);protein, Clone 2TP2C2
Monoclonal antibody prepared against the Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor binding domain. This product was purified from clone 2TP2C2 hybridoma supernatant by protein G affinity chromatography.
Eurofins Discoverx RBL-2H3 ADORA2A Gq Cell Line, 2 vials. (95-1008C11)
The ADORA2A Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adenosine, NECA) based activation of ADORA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADORA2A, a naturally Gq coupled GPCR. Upon activation of ADORA2A, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay NK3 Tachykinin Receptor Frozen Cells, 2 Vials of Cells. (HTS190RTA)
The Ready-to-Assay NK3 Tachykinin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. tachykinins) based activation of TACR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR3 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of TACR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen PK2 Prokineticin Receptor Stable Cell Line, 2 vials. (HTS182C)
The ChemiScreen PK2 Prokineticin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PROKR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PROKR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay S1P1 Lysophospholipid Receptor Frozen Cells, 2 Vials of Cells. (HTS176RTA)
The Ready-to-Assay S1P1 Lysophospholipid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. S1P) based activation of S1PR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses S1PR1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of S1PR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay EP2 Prostanoid Receptor Frozen Cells, 2 Vials of Cells. (HTS185RTA)
The Ready-to-Assay EP2 Prostanoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER2 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of PTGER2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Quantitative Genomic DNA from; Aspergillus fumigatus; Strain: 118
Quantitative Genomic DNA from Aspergillus fumigatus strain NRRL 163 can be used for assay development, verification, validation, monitoring day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine fungal load.
Eurofins Discoverx KILR A549 Cell Pool, 2 vials. (97-1005P015)
The KILR A549 cell pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of A549 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR cell pool. This stable cell pool is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kilr.